MGN1703, an immunomodulator and toll-like receptor 9 (TLR-9) agonist: From bench to bedside
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چکیده
منابع مشابه
Design and Structural Requirements of the Potent and Safe TLR-9 Agonistic Immunomodulator MGN1703
Single-stranded oligodeoxynucleotides (ODN), containing nonmethylated cytosine-guanine motifs (CpG ODN), are recognized by the innate immune system as "danger signals." CpG ODN are efficacious immunomodulators but require phosphorothioate (PT) or other backbone modifications for metabolic stability, which cause toxicities in mice and primates. We therefore designed a covalently closed DNA molec...
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Toll-like receptor 9 (TLR9) is a cellular DNA receptor of the innate immune system. DNA recognition via TLR9 results in an inflammatory reaction, which eventually also activates a Th1-biased adaptive immune attack. In addition to cells of the immune system, TLR9 mRNA and protein are also widely expressed in breast cancer cell lines and in clinical breast cancer specimens. Although synthetic TLR...
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Address for correspondence: Michał Sobjanek MD, PhD, Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 1a Kliniczna St, 80-402 Gdansk, Poland, phone: +48 607 039 729, e-mail: [email protected] Received: 8.01.2016, accepted: 20.04.2016. The ethiopathogenesis of psoriasis is complex, multifactorial and still not well understood. Nowadays, the systemic, inflammator...
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ژورنال
عنوان ژورنال: Critical Reviews in Oncology/Hematology
سال: 2015
ISSN: 1040-8428
DOI: 10.1016/j.critrevonc.2014.12.002